Aminoglycosides are a class of antibiotics commonly used to treat severe bacterial infections, but their use carries a significant risk of ototoxicity, especially in individuals with certain genetic predispositions. One such factor is the MT-RNR1 gene mutation, specifically the m.1555G variant, which greatly increases the risk of aminoglycoside-induced hearing loss. Early detection of this genetic variant is essential to prevent irreversible hearing damage in patients requiring aminoglycoside treatment.
Current genetic testing methods are limited by long processing times and the need for specialized laboratory facilities, highlighting the urgent need for a rapid, reliable, and accessible testing solution.
VitaSIRO solo™
MT-RNR1 SNP Assay
REGISTRATION STATUS
Research Use Only
VitaSIRO solo™ – Molecular Diagnostics at Your Fingertips.
To meet the need for rapid genetic testing, Credo Diagnostics Biomedical has developed a POCT assay that detects the Mt-RNR1 Single Nucleotide Polymorphism linked to aminoglycoside-induced hearing loss. The assay targets the m.1555G variant and its wild-type counterpart, with a built-in control to ensure reliable results.
This test delivers accurate results in just 20 minutes, enabling clinicians to quickly tailor treatments based on genetic profiles and prevent hearing loss. By bringing genetic testing to the point of care, this solution supports timely, informed decision-making and improves patient outcomes.
Usability
- Minimal Training Required
- No additional equipment needed
- Room Temperature Storage
Performance
- Extraction-Free Assay
- < 3-minute hands-on time
- Targeting m.1555G, wild type and Sample Adequacy Control for reliable result
Diagnostic Procedure in 4 Steps
Collect
Collect sample
Lyse
Lyse the sample
thoroughly for 15 times
Transfer
Transfer the sample
Start Run
Results reported in
20 minutes
Collect
Collect sample
Lyse
Lyse the sample
thoroughly for 15 times
Transfer
Transfer the sample
Start Run
Results reported in
20 minutes
Intuitive Result Interpretation
VitaSIRO solo™ MT-RNR1 SNP Assay
Catalog No.
PCRAD1115
Technology
Direct Lysis + Real-Time PCR
Quantity
20 test/box
Targets
• m.1555G
• Wild type gene
• Sample Adequacy Control (SC)
Sample Types
Buccal Swab
Hands-on Time
< 1 minute
Turnaround Time
20 mins
Kit Storage
5~25°C
