Group A Streptococcus (GAS) is the cause of several human infectious diseases, ranging from minor illnesses to deadly diseases. The infection usually starts from the throat, tonsils, or skin, and it occurs more commonly in children than adults. The conventional detection methods of GAS infection include rapid antigen testing or throat culture. A throat culture is more sensitive than rapid tests, but its long turnaround time makes it difficult to provide clinicians with a timely diagnosis. Therefore, to help clinicians for better antimicrobial stewardship, fast and accurate testing for GAS detection is needed, which also prevents the spread of the disease and further complications like rheumatic fever.